Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP-dependent RNA DHX15 helicase | the enzyme acts poorly on capped RNA molecules whose 5'-terminal residues are base-paired to form secondary structure. However, the enzyme uses its G-patch domain to form a strong complex with ATP-dependent RNA, which significantly improves the efficiency of cap1 methylation of such RNAs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in High Five insect cells and HEK-293 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] | Homo sapiens | - |
S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
HiTrap heparin column chromatography and HIS Select nickel affinity gel filtration and HiTrap Q column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] | - |
Homo sapiens | S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 95000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CMTr1 | - |
Homo sapiens |
RNA cap1 methyltransferase | - |
Homo sapiens |